Definition of the week: Discombobulate

As in: Karen just returned to work from a two-week vacation and she is all discombobulated.

Discombobulate
From m-w.org

Main Entry: dis·com·bob·u·late
Pronunciation: \ˌdis-kəm-ˈbä-b(y)ə-ˌlāt\
Function: transitive verb
Inflected Form(s): dis·com·bob·u·lat·ed; dis·com·bob·u·lat·ing
Etymology: probably alteration of discompose
Date: circa 1916

: upset, confuse

— dis·com·bob·u·la·tion \-ˌbä-b(y)ə-ˈlā-shən\ noun